Regulation of atrial natriuretic peptide (ANP) and its role in blood pressure

Authors

  • Feroz Ahmed Department of Pharmaceutical Sciences Pharmacology Division University of Kashmir Srinagar-190 006
  • Nahida Tabassum Department of Pharmaceutical Sciences Pharmacology Division University of Kashmir Srinagar-190 006
  • Saima Rasool Department of Pharmaceutical Sciences Pharmacology Division University of Kashmir Srinagar-190 006

DOI:

https://doi.org/10.3329/icpj.v1i7.10812

Keywords:

Atrial natriuretic peptide, ANP receptors, Hypertension, Angiotensin

Abstract

Atrial natriuretic peptide (ANP) a powerful vasodilator, and a protein (28-amino acid peptide) hormone secreted by heart muscle cells. It is released in response to atrial distention, stretching of the vessel walls, sympathetic stimulation of ?-adrenoceptors, raised sodium concentration, angiotensin-II and endothelin. ANP binds to three cell surface receptors called ANP receptors. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system. It has also been reported to increase the release of free fatty acids from adipose tissue. Regulation of its effects is achieved through gradual degradation of the peptide by the enzyme neutral endopeptidase (NEP). Inhibitors of NEP are currently being developed to treat disorders ranging from hypertension to heart failure. Synthetic analogs of ANP have been investigated as potential therapies for the treatment of decompensated heart failure and other diseases.

DOI: http://dx.doi.org/10.3329/icpj.v1i7.10812

International Current Pharmaceutical Journal 2012, 1(7): 176-179

 

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Published

2012-06-03

How to Cite

Ahmed, F., Tabassum, N., & Rasool, S. (2012). Regulation of atrial natriuretic peptide (ANP) and its role in blood pressure. International Current Pharmaceutical Journal, 1(7), 176–179. https://doi.org/10.3329/icpj.v1i7.10812

Issue

Vol. 1 No. 7 (2012)

Section

Review Articles

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