Electrophysiological Changes of Sensory Nerves in Patients with Type-2 Diabetes Mellitus of Different Duration

Authors

  • Sharmeen Sultana Instructor, Department of Physiology, Armed Forces Medical College, Dhaka
  • Noorzahan Begum Professor, Department, Department of Physiology, Bangabandhu Seikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Liaquat Ali Professor, Department of Biochemistry, Department of Neurology, BIRDEM, Dhaka
  • Md Mosharrof Hossain Senior Instructor, Department of Physiology, Armed Forces Medical College, Dhaka
  • Nirmelendu Bikash Bhowmik Associate Professor, Department of Neurology, BIRDEM, Dhaka,
  • Shahana Parveen Associate Professor, Department of Biochemistry, Northern International Medical College, Dhaka
  • Zinia Perveen Instructor, Department of Physiology, Armed Forces Medical College, Dhaka

DOI:

https://doi.org/10.3329/bsmmuj.v3i1.5507

Keywords:

sensory nerves, diabetes mellitus

Abstract

Background: Peripheral neuropathy is a common complication of diabetes mellitus. Among the diabetic neuropathies
symmetrical sensory polyneuropathy is the most common one. Abnormalities of sensory nerve conduction are features
of diabetic nerve damage. Significant association has been found between electrophysiological parameters of sensory
nerves and duration of metabolic derangement in patients with diabetic neuropathy. Objectives: The present study was
designed to characterize nerve conduction abnormalities of sensory nerves in subjects with type 2 diabetes mellitus of
different duration and also to assess whether duration of diabetes has any influence on the sensory nerve function.
Methods: Forty-four type 2 diabetic subjects were included in two groups:- Group B1 consisted of 23 diabetic subjects
having duration of diabetes for 5-10 years (shorter duration) and Group B2 consisted of 21 diabetic subjects having
duration of diabetes for 10-15 years (longer duration). Twenty-five age and BMI matched healthy subjects without
family history of diabetes were included as Group A (control) subjects. Sensory nerve conduction velocities, action
potential amplitudes and latencies of ulnar and sural nerves were measured by a standard NCV-EMG equipment. Result:
No significant changes in sensory nerve conduction parameters were observed in the group of diabetic subjects having
shorter duration of diabetes. In the diabetic group with relatively longer duration of diabetes some of the sensory nerve
conduction parameters were affected. Among them S SNAP and S NCV were significantly (P<0.01 and <0.05 respectively)
reduced in diabetic group with relatively longer duration of diabetes. Conclusion: The results of the study indicated that
neuronal dysfunction for sensory nerves appears after a prolonged exposure to hyperglycemia; there may also be some
genetic and biochemical basis (other than hyperglycemia) for early sensory sparing in type 2 diabetic population of
Bangladesh.

DOI: 10.3329/bsmmuj.v3i1.5507

BSMMU J 2010; 3(1): 9-12

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How to Cite

Sultana, S., Begum, N., Ali, L., Hossain, M. M., Bhowmik, N. B., Parveen, S., & Perveen, Z. (2010). Electrophysiological Changes of Sensory Nerves in Patients with Type-2 Diabetes Mellitus of Different Duration. Bangabandhu Sheikh Mujib Medical University Journal, 3(1), 9–12. https://doi.org/10.3329/bsmmuj.v3i1.5507

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