Incidence of anti-HBc antibody (IgG and IgM) among HBsAg negative apparently healthy blood donors

Nittyananda Shil, Jolly Biswas, Ayesha Khatun, Atiar Rahman, Nahid Sultana, Fatema Easmin, Sonia Sormin


In person who is unable to produce HBsAg, anti-HBc antibody is a helpful marker of hepatitis B virus (HBV) infection. In the present study, we have tried to find out the incidence of anti-HBc (IgG and IgM) among blood donors HBsAg negative. People came for donating blood voluntarily or for their relatives (n = 1000) was selected on inclusion and exclusion criteria. Purposefully selected and collated samples were first tested by HBsAg ELISA of third generation reagent. HBsAg negative sample was tested with anti-HBc ELISA. Positive found in the first test was retested. Out of 1,000 samples on duplicate test, 117 positives were detected. The incidence of anti-HBc antibody among apparently healthy blood donors was found 11.7%.


Anti-HBc antibody; Blood donor; HBsAg; IgG; IgM

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