Studies on the preparation and in vitro - in vivo evaluation of mucoadhesive microspheres of glycyrrhetinic acid isolated from liquorice

Authors

  • Sharad Visht Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, Uttar-Pradesh
  • GT Kulkarni Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, Uttar-Pradesh

DOI:

https://doi.org/10.3329/bpj.v18i1.23511

Keywords:

Mucoadhesive, microspheres, glycyrrhetinic acid, chemical stabilization, polymer, liquorice

Abstract

The present work deals with the formulation and evaluation of mucoadhesive microspheres containing glycyrrhetinic acid. Mucoadhesive microspheres were prepared by single phase emulsification method and heat stabilization method. Chemical stabilization appeared as fast and simple technique for producing glycyrrhetinic acid loaded microspheres. Microspheres prepared by this method produced sufficient production yield, high drug encapsulation efficiency and reproducibility. Among the different formulations, microspheres with drug - polymer ratio of 1:1 (C1) was found to have the maximum mucoadhesive property as well as in vitro and in vivo drug release property. Therefore, it could be considered as the best formulation.

Bangladesh Pharmaceutical Journal 18(1): 30-37, 2015

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Author Biography

Sharad Visht, Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, Uttar-Pradesh



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Published

2015-06-01

How to Cite

Visht, S., & Kulkarni, G. (2015). Studies on the preparation and in vitro - in vivo evaluation of mucoadhesive microspheres of glycyrrhetinic acid isolated from liquorice. Bangladesh Pharmaceutical Journal, 18(1), 30–37. https://doi.org/10.3329/bpj.v18i1.23511

Issue

Vol. 18 No. 1 (2015)

Section

Articles