Synthesis of some pyrazolone derivatives from ciprofloxacin and study of their cytotoxicity

Hari Pado Devnath, Md. Rabiul Islam

Abstract

Three pyrazolone derivativeswith pyrazole ring extensionwere synthesized from ciprofloxacin by treating the parent compound with hydrazine derivatives. All the products have been characterized by IR and 1H-NMR spectral analysis. These derivatives showed potential cytotoxicity against brine shrimp nauplii than the ciprofloxacin.

Keywords

Ciprofloxacin; Cytotoxicity; Pyrazolone

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References

Bekhit AA, Fahmy HT. Design and synthesis of some substituted 1H-pyrazolyl-oxazolidines or 1H-pyrazolyl-thiazolidines as anti-inflammatory-antimicrobial agents. Arch Pharm (Weinheim). 2003; 336: 111-18.

Gürsoy A, Demirayak S, Capan G, Erol K, Vural K. Synthesis and preliminary evaluation of new 5-pyrazolinone derivatives as analgesic agents. Eur J Med Chem. 2000; 35: 359-64.

Islam MR, Khayer K, Ahmad MM. Synthesis of 3-methylpyrazoline-5-one and its 3,3-dimethyl-5,5-ethene-bis-2-pyrazoline-4,4-dione, substituted cyclic tri-azothione and N-acetylated derivatives. J Bangladesh Chem Soc. 2001; 14: 33.

Islam MR, Mohsin M. Synthesis of isatin, 5-chloroisatin and their ∆2 -1,3,4-oxadiazoline derivatives for comparative cytotoxicity study on brine shrimp. Bangladesh J Pharmacol. 2007; 2: 7-12.

Manna F, Chimenti F, Bolasco A, Cenicola ML, D’Amico M, Parrillo C, Rossi F, Marmo E. Anti-inflammatory, analgesic and antipyretic N-acetyl-∆2-pyrazolines and dihydrothienocoumarines. Eur J Med Chem. 1992; 27: 633-39.

Solis PN, Wright CW, Anderson MM, Gupta MP, Phillipson JD. A microwell cytotoxicity assay using Artemia salina (brine shrimp). Planta Med. 1993; 59: 250-52.

Regan J, Capolino A, Cirillo PF, Gilmore T, Graham AG, Hickey E, Kroe RR, Madwed J, Moriak M, Nelson R, Pargellis CA, Swinamer A, Torcellini C, Tsang M, Moss N. Structure activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3yl)-3-[4-(2-morpholin-4-yl-ethoxy) maphthalen-1-yl]urea (BIRB 796). J Med Chem. 2003; 46: 4676-86.

Satyanarayana K, Rao MNA. Synthesis of 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenyl-sydnones as anti-inflammatory, antiarthritic and analgesic agents. Eur J Med Chem. 1995; 30: 641-45.



DOI: http://dx.doi.org/10.3329/bjp.v5i1.4693

Copyright (c) 2010 Hari Pado Devnath, Md. Rabiul Islam

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