Synthesis of some pyrazolone derivatives from ciprofloxacin and study of their cytotoxicity

Hari Pado Devnath, Md. Rabiul Islam

Abstract

Three pyrazolone derivatives with pyrazole ring extension were synthesized from ciprofloxacin by treating the parent compound with hydrazine derivatives. All the products have been characterized by IR and 1H-NMR spectral analysis. These derivatives showed potential cytotoxicity against brine shrimp nauplii than the ciprofloxacin.

Keywords: Cytotoxicity; Pyrazolone; Ciprofloxacin

Online: 29 May 2010   

DOI: 10.3329/bjp.v5i1.4693

Bangladesh J Pharmacol 2010; 5: 30-33

 

 

 

Keywords

cytotoxicity; pyrazolone; Ciprofloxacin

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DOI: http://dx.doi.org/10.3329/bjp.v5i1.4693

Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is the peer-reviewed, open access official publication of the Bangladesh Pharmacological Society. Papers are published immediately after acceptance.

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