Sequential treatment with ursolic acid chlorophenyl triazole followed by 5-fluorouracil shows synergistic activity in small cell lung cancer cells

Authors

  • Rui-Xia Zhu Department of Oncology, Zaozhuang Mining Group Central Hospital, Zaozhuang, 277800
  • Lei Zhao Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011
  • Yu-Kun Zhang Department of Thoracic Surgery, Taian Central Hospital, Taian, 271000
  • Peng Luo Shanghai Topgen Biopharm Co., Ltd, Shanghai 200 000
  • Si-Hai Liu Department of Oncology, Zaozhuang Mining Group Central Hospital, Zaozhuang, 277800
  • Jin-Guang Wang Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011

DOI:

https://doi.org/10.3329/bjp.v10i1.21641

Keywords:

Apoptosis, Cytotoxic, 5-Fluorouracil, Neoplasm, Synergistic

Abstract

Combination therapy has prolonged the survival of patients with small cell lung cancer (SCLC), an aggressive neoplasm characterized by a high rate of metastasis. In the present study the effect of sequential treatment of ursolic acid chlorophenyl triazole (UACT) followed by 5-fluorouracil (5-FU) on human small cell lung cancer cells was investigated. The results revealed a synergistic effect of the sequential treatment with UACT and 5-FUcombination on cytotoxic activities, NF-kB protein activation, repression of TNF-induced NF-kB-dependent reporter gene expression, and TNF-induced COX-2, MMP-9 and Cyclin D1 activation in H209 cells. The synergism in apoptotic cell death was observed in H209, H69, 87-5,and Lu135 cells. The synergistic effect of UACT and 5-FU was observed at a concentration of 50 nM of UACT and 20 µM of 5-FU. These results indicate that UACT and 5-FU combination can be a promising chemotherapeutic regimen in the treatment of SCLC.

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Published

2015-03-09

How to Cite

Zhu, R.-X., L. Zhao, Y.-K. Zhang, P. Luo, S.-H. Liu, and J.-G. Wang. “Sequential Treatment With Ursolic Acid Chlorophenyl Triazole Followed by 5-Fluorouracil Shows Synergistic Activity in Small Cell Lung Cancer Cells”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Mar. 2015, pp. 197-04, doi:10.3329/bjp.v10i1.21641.

Issue

Vol. 10 No. 1 (2015)

Section

Research Articles

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