Targeting breast cancer using retinoic acid trifloromethyl chalcone: A promising therapeutic strategy in the treatment of breast cancer

Authors

  • Hao Ding Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
  • Ben-Zhong Wang Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
  • Hua-Qing Zhu Department of Biochemistry, Anhui Medical University, Hefei 230022
  • Liu-Yi Dong Department of Pharmacology, Anhui Medical University, Hefei 230022
  • Yu-Fang Gu Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
  • Yu Zhao Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022

DOI:

https://doi.org/10.3329/bjp.v10i1.21599

Keywords:

Breast cancer, Retinoic acid trifloromethyl chalcone, Therapeutic strategy

Abstract

The study was devised to investigate the effect of retinoic acid trifloromethyl chalcone (RAFC) on mammary carcinogenesis in female rats. The data revealed a significant decrease in number of rats with mammary tumor, number of tumors per rat and tumor volume by 54, 72 and 75% respectively in RAFC group compared to control group. The ibuprofen treated rats also showed a significant decrease in number of rats with tumor, number of tumors per rat and tumor volumes by 43%, 55%, and 59%, respectively. Treatment of rats with RAFC also increased the latency period of tumor induction significantly. Median detection period (50% of tumors) was 92, 83 and 56 days respectively in the rats from RAFC, ibuprofen and control groups respectively after DMBA induction. These results demonstrate that RAFC possesses strong chemopreventive activity against mammary carcinogenesis. 

Downloads

Download data is not yet available.
Abstract
1552
Download
690 Read
383

Downloads

Additional Files

Published

2015-03-11

How to Cite

Ding, H., B.-Z. Wang, H.-Q. Zhu, L.-Y. Dong, Y.-F. Gu, and Y. Zhao. “Targeting Breast Cancer Using Retinoic Acid Trifloromethyl Chalcone: A Promising Therapeutic Strategy in the Treatment of Breast Cancer”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Mar. 2015, pp. 209-13, doi:10.3329/bjp.v10i1.21599.

Issue

Vol. 10 No. 1 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).