In vivo hypoglycemic study of Manilkara zapota leave and seed extracts

Authors

  • Saikat Ranjan Paul Department of Pharmacy, Southeast University, Dhaka
  • Md. Lukman Hakim Department of Pharmacy, Southeast University, Dhaka

DOI:

https://doi.org/10.3329/bjp.v10i1.21475

Keywords:

Alloxan, Diabetes mellitus, Hypoglycemia, Manilkara zapota

Abstract

The hypoglycemic activity of pet-ether extracts of leaves and methanol extracts of seeds of Manilkara zapota was evaluated in the study. The oral glucose tolerance test was performed in mice treated with 2 mg/kg glucose solution and the blood glucose level was determined after 15, 30, 60, 90 and 120 min of administration. Alloxan (70 mg/kg) was injected intravenously to induce diabetes in mice. The hypoglycemic study was carried out 7 days. In glucose tolerance test all extracts achieved significant p values (p<0.0001) at 60, 90 and 120 minutes compared to the glucose control. In hypoglycemic study all extracts started to reduce the blood glucose level rapidly even starting from the 2nd day of treatment and significant p values (p<0.0001) were achieved. So, the study evinced the hypoglycemic potency of the leave and seed extracts of M. zapota.

Downloads

Download data is not yet available.
Abstract
1948
Download
2427 Read
1792

Downloads

Additional Files

Published

2015-03-20

How to Cite

Paul, S. R., and M. L. Hakim. “In Vivo Hypoglycemic Study of Manilkara Zapota Leave and Seed Extracts”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Mar. 2015, pp. 246-50, doi:10.3329/bjp.v10i1.21475.

Issue

Vol. 10 No. 1 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).