Analgesic and anti-inflammatory activities of leaf extract of Kydia calycina Roxb.

Baburao Bhukya, Rama Narsimha Reddy Anreddy, Carey M. William, Krishna Mohan Gottumukkala

Abstract

The methanol extract of leaves of Kydia calycina Roxb. was screened for the analgesic (using hot plate test and acetic acid-induced writhing test in mice) and anti-inflammatory (using rat paw edema test) activity at the doses of 200 and 400 mg/kg body weight. A significant (p<0.0005) analgesic effect was observed with 200 mg/kg and 400 mg/kg in both tests. The maximum anti-inflammatory response was produced at 3 hour with extract doses of 200 and 400 mg/kg. These results suggest that the methanol extract of K. calycina hasexhibited significant analgesic and anti-inflammatory effects, which were comparable with standard drugs.

Keywords

Analgesic; Anti-inflammatory; Carrageenan; Kydia calycina

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DOI: http://dx.doi.org/10.3329/bjp.v4i2.2112

Copyright (c) 2009 Baburao Bhukya, Rama Narsimha Reddy Anreddy, Carey M. William, Krishna Mohan Gottumukkala

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