Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions

Authors

  • Jian Yang Yantai Blood Center, Yantai, Shandong 264000
  • Ji-Xia Li Department of Clinical Laboratory, Yantaishan Hospital, Yantai, Shandong 264000
  • Zhe Song Department of Quality Control, Yantai Blood Center, Yantai, Shandong 264000
  • Xi-Yan Xia Jinan Nursing Vocational College, Jinan Shandong 250000

DOI:

https://doi.org/10.3329/bjp.v10i1.20498

Keywords:

Allergic Transfusion Reactions, Traditional Chinese Medicine, Anti Histamine, Histidine decarboxylase, Molecular Dynamics Simulation

Abstract

Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM) Cordyceps, as a potential inhibitor of histidine decarboxylase. The approach of molecular docking and Molecular Dynamics Simulation (MDS) on a traditional anti-inflammatory Chinese medicine gave an atomic insight of the inhibition. The daucosterol was binding with a ?G of -3.17 Kcal/mol, to inhibit histamine synthesis by binding to histidine decarboxylase, possibly via the flexible catalytic loop. Such inhibitors that were designed to block the flexibility of the catalytic loop are potential candidates for further drug development program.

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Author Biography

Jian Yang, Yantai Blood Center, Yantai, Shandong 264000

Professor and Head

Published

2015-01-05

How to Cite

Yang, J., J.-X. Li, Z. Song, and X.-Y. Xia. “Daucosterol Derived from Cordyceps (a Traditional Chinese Medicine) As a Possible Lead Compound for Allergic Transfusion Reactions”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Jan. 2015, pp. 35-39, doi:10.3329/bjp.v10i1.20498.

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Section

Research Articles