Potential anti-diabetic activity of Bombax ceiba

Chetan Bhavsar, Gokul S. Talele

Abstract

Bombax ceiba bark extract was evaluated for its hypoglycemic and hypolipide-mic potential through normal and streptozotocin-induced diabetic rats administered with graded oral doses (200, 400, 600 mg/kg/day) for 21 days. The results showed that a dose of 600 mg/kg of B. ceiba extract is the most effective to cause significant (p<0.001) hypoglycemic and/or hypolipidemic effects on  streptozotocin-induced diabetic rats. This dose also significant-ly (p<0.001) lowered the total cholesterol and triglyceride level in severely diabetic rats. Phytochemical and GC-MS studies confirmed the presence of the triterpenoid compounds in the extract, which may account for its significant hypoglycemic activity. The present study thus provides a scientific rationale for the traditional use of this plant in the management diabetes.

 

 

Keywords

Kantesavar, Toranmal, Hypoglycemic, Hypolipidemic, Streptozotocin

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References

Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974; 20: 470–75.

Ansari MM, Ahmad J, Ahmad A, Ansari SH. Pharmacognos-tical, phytochemical and biological evaluations of the stem bark of Bombax ceiba Linn. (Semul). Hamdard Med. 2007; 50: 119-33.

Gandhare B, Soni N Hemant JZ. In vitro antioxidant activity of Bombax ceiba. Int J Biomed Res. 2012; 1: 31-36.

Bierman EL, Amaral JAP, Belknap BH. Hyperlipidemia and diabetes mellitus. Diabetes 1966; 15: 675-79.

Burstein M, Scholnick HR, Morfin R. Rapid method for isolation of lipoprotein from human serum by precipitation with polyanions. J Lipid Res. 1970; 11: 583–95.

Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia 2000; 43: 1528-33.

Esmaeili MA, Yazdanparas R. Hypoglycemic effect of Teucrium polium: Studies with rat pancreatic islets. J Ethnopharmacol. 2004; 95: 27-30.

Faizi S, Zikr-Ur-Rehman S, Versiani MA. Shamiminol: a new aromatic glycoside from the stem bark of Bombax ceiba. Nat Prod Commun. 2011; 6: 1897-900.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.

Hai-Xue Kuang, Hong-Wei Li, Qiu-Hong Wang, Bing-You Yang, Zhi-Bin Wang, Yong-Gang Xia. Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba Molecules 2011; 16: 4642-51.

Jacques RA, Santos JG, Darivab C, Vladimir Oliveira J, Caramao EB. GC/MS characterization of mate tea leaves extracts obtained from high-pressure CO2 extraction. J Supercritic Fluids 2007; 40: 354-59.

Kedar P, Chakrabarti CH. Effects of bittergourd Momordica charantia seed and glibenclamide in streptozotocin induced diabetes mellitus. Indian J Exp Biol. 1982; 20: 232-35.

Kirtikar KR, Basu BD. Indian medicinal plants. Vol II, 2nd edn. Dehradun, International Book Distribution, 1987.

Muller PH, Schmulling RM, Liebih HM, Eggstein M. A fully enzymatic triglyceride determination. J Clin Chem Clin Biochem. 1977; 15: 457–64.

Patel SS, Verma NK, Rathore B, Nayak G, Singhai AK, Singh P. Cardioprotective effect of Bombax ceiba flowers against acute adriamycin-induced myocardial infarction in rats. Rev Bras Farmacogn 2011; 21: 704-09.

Sugihara Y, Nojima H, Matsuda H, Murakami T, Yoshikawa M, Kimura I. Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. J Asian Nat Prod Res. 2000; 2: 321-27.

Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol. 2008; 15: 263-73.

The wealth of India, dictionary of Indian raw material and Industrial products. Vol-II:B. Publication and Information Directorate, CSIR, New Delhi, 2005.

Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem. 1969; 6: 24–27.

Verma V, Jalalpure SS, Sahu A, Lokesh KB, Yache P. Bombax ceiba Linn: Pharmacognostical, phytochemistry, ethnobo-tany, and pharmacology studies. Internatinale Pharmacutica Sci. 2011; l: 62-68.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes, estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-53.



DOI: http://dx.doi.org/10.3329/bjp.v8i2.13701

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