Xanthine oxidase inhibitory activity of compounds from Chythrantus claneianus

Authors

  • Anar Sahib Gojayev Department of Biochemistry and Biotechnology, Faculty of Biology, Baku State University, AZ 1148
  • Jean Jules Kezetas Bankeu Department of Chemistry, Faculty of Science, University of Bamenda, P. O. Box 39 Bambili
  • Angelbert Fusi Awantu Department of Chemistry, Faculty of Science, University of Bamenda, P. O. Box 39 Bambili
  • Eric René Sieliatchom Nkanwen Chemistry Department, Faculty of Science, University of Dschang, P.O. Box 67, Dschang
  • Muhammad Shaiq Ali I.C.C.B.S., International Center for Chemical and Biological Sciences, University of Karachi 75270
  • Bruno Ndjakou Lenta Higher Teachers Training College, University of Yaoundé I, P.O. Box 47, Yaoundé
  • Akif Alakbar Guliyev Department of Biochemistry and Biotechnology, Faculty of Biology, Baku State University, AZ 1148
  • Didérot Tchamo Noungoué TWAS Research Unit, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812 Yaoundé
  • Silvère Augustin Ngouela TWAS Research Unit, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812 Yaoundé
  • Etienne Tsamo TWAS Research Unit, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812 Yaoundé

DOI:

https://doi.org/10.3329/bjp.v8i1.13485

Keywords:

Chythrantus claneianus, rheumatism, xanthine oxidase inhibitor

Abstract

Phytochemical investigation of the stem bark and the trunk of Chythrantus claneianus led to the isolation of six known compounds named β-sitosterol (1), umbelliferone (2), scopoletin (3), benjaminamide (4), β-sitosterol-3-O-β-D-glucopyranoside (5) and panconoside B (6). All these compounds were isolated for the first time from this plant species. The chemical structures of isolates were elucidated on the basis of 1 and 2 D-NMR spectra and other spectroscopic techniques including UV–vis, FT-IR, HR-ESIMS and HR-FABMS. The isolates were tested in vitro for their inhibitory properties towards xanthine oxidase enzyme. Compounds 2, 3 and 6 showed weak inhibitory activities on the enzyme with IC50 values ranging from 307 µM for compound 6 to 475 µM for compound 3, while the extract and compounds 1, 4 and 5 showed extremely weak activities with inhibition percentage less than 50%.

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Published

2013-02-04

How to Cite

Gojayev, A. S., J. J. K. Bankeu, A. F. Awantu, E. R. S. Nkanwen, M. S. Ali, B. N. Lenta, A. A. Guliyev, D. T. Noungoué, S. A. Ngouela, and E. Tsamo. “Xanthine Oxidase Inhibitory Activity of Compounds from Chythrantus Claneianus”. Bangladesh Journal of Pharmacology, vol. 8, no. 1, Feb. 2013, pp. 78-83, doi:10.3329/bjp.v8i1.13485.

Issue

Vol. 8 No. 1 (2013)

Section

Research Articles

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