Effect of Sechium edule on chemical induced kidney damage in experimental animals
DOI:
https://doi.org/10.3329/bjp.v8i1.12982Keywords:
Diabetic nephropathy, Gentamicin, Potassium dichromate, Sechium edule, StreptozotocinAbstract
The aqueous extract of leaves of Sechium edule was evaluated for its protective activity against gentamicin, potassium dichromate-induced nephrotoxicity and streptozotocin-induced diabetic nephropathy in experimental animals. In these three conditions, the extract of S. edule (200 mg/kg) has significantly (p<0.001) decreased the level of blood urea, blood urea nitrogen and serum creatinine and also significantly (p<0.001) increased the serum levels of total protein. The serum uric acid level was also significantly (p<0.001) decrease in diabetic mice treated with the extract (200 mg/kg). The extract also improves the histology of the kidney. The results indicate that aqueous extract of leaves of S. edule has possessed protective effect against gentamicin- and potassium dichromate-induced nephrotoxicity and streptozotocin-induced diabetic nephropathy in experimental animals.
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Albone KS, Gaskin P, MacMillan J, Sponsel VM. Identification and localization of gibberlins in maturing seed of cucurbit Sechium edule, and a comparison between this cucurbit and the legume Phaseolus coccineus. Planta springer-verla. 1984; 162: 560-65.
Firdous SM, Sravanthi K, Debnath R, Neraja K. Protective effect of ethanolic extract and its ethylacetate and n-butanol fractions of Sechium edule fruits against carbon tetrachloride induced hepatic injury in rats. Int J Pharm Pharm Sci. 2012; 4: 354-59.
Firdous SM, Neraja K, Debnath R, Singha D, Sravanthi K. Evaluation of antiulcer activity of ethanolic extract of Sechium edule fruits in experimental rats. Int J Pharm Pharm Sci. 2012; 4: 374-77.
Franchini I, Mutti A, Cavatorta A, Corradi A, Cosi A, Olivetti G, Borghetti A. Nephrotoxicity of chromium. Remarks on an experimental and epidemiological investigation. Contrib Nephrol. 1978; 10: 98110.
Gordon EA, Guppy LJ, Nelson M. The antihypertensive effects of the Jamaican Cho-Cho (Sechium edule). West Ind Med J. 2000; 49: 27-31.
Harborne JB. Textbook of phytochemical methods. 1st ed. London, Champraan and Hall Ltd., 1973, pp 110-13.
Harlalka GV, Patil CR, Patil MR. Protective effect of Kalanchoe pinnata pers. (crassulaceae) on gentamicin-induced nephrotoxicity in rats. Indian J Pharmacol. 2007; 39: 201-05.
Kamble MB, Dumbre RK, Rangari VD. Hepatoprotective activity studies of herbal formulations. Int J Green Pharm. 2008; 2: 147-51.
Lelli JL, Becks LL, Dabrowska MI, Hinshaw DB. ATP converts necrosis to apoptosis in oxidant-injured endothelial cells. Free Radic Biol Med. 1998; 25: 694702.
Parveen K, Khan R, Siddiqui WA. Pycnogenol prevents potassium dichromate (K2Cr2O7)-induced oxidative damage and nephrotoxicity in rats. Chemico-Biol Interact. 2009; 181: 34350.
Pedraza-Chaverri J, Barrera D, Medina-Campos ON, Carvajal RC, Hernández-Pando R, Macías-Ruvalcaba NA, Maldonado PD, Salcedo MI, Tapia E, Saldívar L, Castilla ME, Ibarra-Rubi ME. Time course study of oxidative and nitrosative stress and antioxidant enzymes in K2Cr2O7 induced nephrotoxicity. BMC Nephrol. 2005; 26: 4.
Poormoosavi SM, Behmanesh MA, Najafzadeh H. Effect of cimetidine on gentamicin-losartan induced-nephrotoxicity in rats. Afr J Pharm Pharmacol. 2010; 4: 341-45.
Punitha ISR, Shirwaikar A, Shirwaikar A. Antidiabetic activity of benzyl tetra isoquinoline alkaloid berberine in streptozotocin nicotinamide induced type 2 diabetic rats. Diabetologia Croatica. 2005; 34: 117-28.
OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the OECD guidelines for the testing of chemicals organisation for economic co-operation development, Paris, June, 2000.
Ordonez AA, Gomez JD, Isla MA. Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem. 2006; 97: 452-58.
Shi X, Chiu A, Chen CT, Halliwell B, Castranova V, Vallyathan V. Reduction of chromium (VI) and its relationship to carcinogenesis. J Toxicol Environ Health. 1999; 2: 87-104.
Siciliano T, De Tommasi N. Study of Flavonoids of Sechium edule (Jacq) swartz (Cucurbitaceae) Different Edible Organs by Liquid Chromatography Photodiode array Mass Spectrometry. J Agric Food Chem. 2004; 52: 651015.
Siddiqui O, Sun Y, Lin JC, Chien YW. Facilitated transdermal transport of insulin. J Pharm Sci. 1987; 76: 341-45.
Vozari-Hampe MM, Viegas C, Saucedo C, Rosseto S, Manica GG, Hampe OG. A lectin from Sechium edule fruit exudates. Phytochem. 1992; 31: 1477-80.
Wilson JS, Ganesan K, Palanisamy M. Effect of sinapic acid on biochemical markers and histopathological studies in normal and streptozotocin-induced diabetes in wistar rats. Int J Pharm Pharm Sci. 2011; 3(4 Suppl): 115-20.
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