Evaluation of the antibody response against Hepatitis B Virus infection in patients on maintenance hemodialysis: A Pilot Study

Authors

  • S Shahin Assistant Professor, Department of Microbiology, Shahabuddin Medical College, Dhaka
  • Md Khoybar Ali Assistant Professor, Department of Paediatrics, Ibn Sina Medical College, Dhaka
  • A Farhana Assistant Professor, Department of Biochemistry, Uttara Adhunic Medical College, Dhaka
  • K Matira Assistant Professor, Department of Pharmacology & Therapeutics, Shahabuddin Medical College, Dhaka

DOI:

https://doi.org/10.3329/bjms.v8i1.3185

Keywords:

Hepatitis B virus, Antibody response, Hemodialysis

Abstract

Objective: This study was undertaken to evaluate the antibody response of hepatitis B virus infection in patients on maintenance hemodialysis (MHD) by detecting different viral markers.
Method: Study subjects comprised a total of 88 chronic kidney disease (CKD) patients from Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) and Bangabandhu Sheikh Mujib Medical University (BSMMU). Of them 63 patients on MHD and 25 predialysis patients served as cases and controls respectively. Clinical history was taken and serological markers for HBV (HBsAg, Anti-HBs, and Anti-HBc) were determined by using ELISA.
Results: Hepatitis B virus was positive in 1.6% of maintenance hemodialysis (MHD) patients and in 16% of controls (p<0.02). Anti-HBc antibody was positive in 62% of dialysis patients and 72% of controls (p=NS) and the positivity was significantly associated in dialysis subjects with longer duration of dialysis (18 ± 22 vs. 10 ± 7, months, p<0.04), multiple units of blood transfusions (22 ± 29 vs. 10 ± 12, units, p<0.04) and more reuse of dialyzer (3 ± 1 vs. 2 ± 1, times, p<0.03) than the negative ones. Among MHD patients 84% were vaccinated against HBV with a schedule of 3 (79%) and 4 (21%) doses and protective antibody titer (>10 IU/L) was found in 57%. None of the controls were vaccinated but 66% had protective titer indicating post exposure natural immunity.
Conclusions: Hepatitis B virus positivity was significantly higher among the predialysis subjects compared to dialysis group.

Key words: Hepatitis B virus, Antibody response, Hemodialysis

doi: 10.3329/bjms.v8i1.3185

Bangladesh Journal of Medical Science Vol.8 No. 1-2; 2009 15-21

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Author Biography

Md Khoybar Ali, Assistant Professor, Department of Paediatrics, Ibn Sina Medical College, Dhaka

Dr Md Khoybar Ali FCPS. Assistant Professor, Department of Paediatrics, Ibn Sina Medical College, 1/1B Kalyanpur, Mirpur Road, Dhaka-1216, Bangladesh.

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How to Cite

Shahin, S., Ali, M. K., Farhana, A., & Matira, K. (2009). Evaluation of the antibody response against Hepatitis B Virus infection in patients on maintenance hemodialysis: A Pilot Study. Bangladesh Journal of Medical Science, 8(1), 15–22. https://doi.org/10.3329/bjms.v8i1.3185

Issue

Vol 8, No1&2, 2009

Section

Original Articles

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