Confocal Laser Endomicroscopy in Diagnostics of Complications of Gastroesophageal Reflux Disease in Children

Anton Andreevich Shavrov, Igor Vitalevich Kirgizov, Andrey Alexandrovich Shavrov, Anastasiya Yurevna Kharitonova, Alexander Gavrilovich Talalaev, Galina Vasilevna Volynets, Sergei Germanovich Khomeriki

Abstract

Twenty-nine children with suspected gastroesophageal reflux disease (GERD) and 17 children as a reference group were enrolled in the study. A conventional white light endoscopy of the oesophagus was supplemented by a probe-based confocal laser endomicroscopy (pCLE) and followed by a biopsy for histological examination. A comparative analysis of endoscopic, endomicroscopic, and histological data were performed. The pCLE allows detecting oesophagitis with the sensitivity and specificity of 93% and 94%, respectively; gastric and intestinal metaplasia typical for Barrett oesophagus with 83% and 100%, respectively; and polyps of the cardioesophageal passage with the sensitivity of 89% in patients with long-term GERD. Thus, this method allows taking an optical biopsy of pathological changes of esophageal mucosa just during the standard endoscopic investigation.

DOI: http://dx.doi.org/10.11593/bje.2013.0102.0012

Bangladesh Journal of Endosurgery Vol.1(2) May 2013: 1-6

Keywords

Confocal laser endomicroscopy; Gastroesophageal reflux disease; Polyps of cardioesophageal passage; Pediatrics; Barrett oesophagus; GERD; Children; pCLE

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