Better in-hospital outcome among hypertensive subjects developing acute myocardial infarction-study in a tertiary cardiac care center in Bangladesh

Prabir Kumar Das, Sayed Md Hasan, Salehuddin Siddique, Munzur Murshed, AKM Fazlur Rahman

Abstract

Background:In-hospital complications and mortality in hypertensives developing acute myocardial infarction(AMI) may be different from those of normotensive counterpart.The aim of the current study was to analyze in-hospital complication and outcome of AMI in hypertensive patients and compare it with age and sex matched normotensive AMI patients.

Methods: In-hospital complications of 112 hypertensive patients with AMI admitted over a period of 1 year (April 2014 to March 2015) were compared with the control group. Location and types of AMI were determined by ECG. Patients were considered to be hypertensive if they were taking antihypertensive treatment or were found to have a systolic blood pressure (SBP) e”140 mmHg and/or a diastolic blood pressure (DBP) e”90 mmHg on repeated measurements. Both groups were studied prospectively. The results were analyzed by SPSS software.

Results:Out of total 112 patients 69 were male and 43 were female in each group. Male: female ratio was 1.6:1. Mean age of the study population was 67.3±10.2 yrs (range 41 to 83 yrs). Mean blood pressure values were 145.7±11.5/88.3±8.9 mmHg in the hypertensive and 127.3±9.7/75.8±5.6 mmHg in normotensive group respectively. A significantly higher prevalence of diabetes, dyslipidemia, chronic kidney disease, stroke and peripheral vascular disease were found in the hypertensive compared with the normotensive subjects. Hypertensive AMI patients had higher left ventricular ejection fraction compared with the normotensives(0.51±0.13 vs 0.47±0.15). A higher frequency of paroxysmal atrial fibrillation(AF) (10.7% vs 7.1%, P<0.05) and a lower frequency of atrioventricular block (5.4 % vs 8.0%), ventricular fibrillation (2.7% vs 4.5%), cardiogenic shock (4.5% vs 9.8%, P<0.01) and a lower inhospital mortality(6.2% vs 10.7%, P<0.01) were found among the hypertensives compared with the normotensives.

Conclusion: Hypertensive AMI patients had a significantly higher incidence of AF, lower incidence of cardiogenic shock and an overall better inhospital outcome compared with the normotensives, probably owing to a better preserved left ventricular function, prior use of cardioprotective drugs and yet undefined mechanism.

Bangladesh Heart Journal 2016; 31(1) : 10-17

Keywords

Hypertension; AMI,Outcome

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DOI: http://dx.doi.org/10.3329/bhj.v31i1.30615

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